2022 NFL2 DEF Points
| Player | Team | Total | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 |
| San Francisco | Vikings | 193 | 15 | 24 | 15 | 27 | 19 | 6 | -1 | 14 | bye | 15 | 12 | 19 | 18 | 10 |
| Philadelphia | Club CC | 148 | 6 | 24 | 21 | 4 | 8 | bye | 16 | 11 | 7 | 13 | 5 | 20 | 13 | |
| Buffalo | Goats | 148 | 22 | 28 | 17 | 9 | 11 | 6 | bye | 5 | 7 | 4 | 3 | 10 | 13 | 13 |
| New England | Lemurs | 132 | 10 | 16 | 4 | 7 | 38 | bye | 33 | 1 | 3 | 20 | ||||
| Dallas | Dragons | 131 | 12 | 20 | 10 | 19 | 10 | bye | 2 | 26 | 8 | 19 | 5 | |||
| Tampa Bay | Shotcallers | 122 | 19 | 24 | 9 | 1 | 14 | 9 | 3 | 0 | 18 | 12 | bye | 6 | 9 | -2 |
| Baltimore | Contributors | 118 | 10 | 5 | 6 | 13 | 9 | 6 | 17 | bye | 23 | 6 | 13 | 10 | ||
| Denver | 107 | 12 | 16 | 21 | 2 | 15 | 9 | 12 | 9 | bye | 7 | 1 | 3 | |||
| Miami | Twism | 99 | 22 | -4 | 5 | 0 | 2 | 11 | 10 | 0 | 7 | 10 | bye | 27 | 5 | 4 |
| Cincinnati | Lunatics | 80 | 10 | 4 | 14 | 6 | 15 | 13 | bye | 1 | 5 | 4 | 8 | |||
| LA Rams | 77 | 4 | 12 | 6 | 4 | 14 | 19 | bye | 2 | 6 | 5 | 5 | ||||
| NY Jets | Destroyers | 69 | 9 | 13 | 14 | 11 | 6 | 16 | ||||||||
| Tennessee | 55 | 20 | 21 | dnp | 14 | dnp | ||||||||||
| Cleveland | 50 | 1 | 13 | 5 | 31 | |||||||||||
| New Orleans | 36 | 1 | 12 | 10 | 4 | 3 | 6 | |||||||||
| Kansas City | Trash Talkers | 35 | 20 | 15 | ||||||||||||
| Green Bay | 33 | 13 | 5 | 6 | 9 | |||||||||||
| Minnesota | 32 | 10 | 10 | bye | 12 | |||||||||||
| Indianapolis | 28 | 9 | 2 | 17 | dnp | |||||||||||
| Pittsburgh | 20 | 19 | 1 | |||||||||||||
| Jacksonville | 16 | 12 | -2 | 6 | ||||||||||||
| Seattle | Demons | 13 | 10 | 3 | ||||||||||||
| NY Giants | 9 | 9 | ||||||||||||||
| Las Vegas | 8 | 8 | ||||||||||||||
| Atlanta | 3 | 3 | ||||||||||||||
| LA Chargers | -3 | -3 |