2021 NFL2 DEF Points
| Player | Team | Total | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 |
| New England | Shotcallers | 140 | 9 | 14 | 8 | 4 | 13 | 21 | 17 | 33 | 9 | 12 | bye | |||
| Buffalo | Club CC | 129 | 7 | 25 | 7 | 30 | 12 | -1 | bye | 10 | 14 | 7 | -3 | 16 | 7 | -2 |
| Cleveland | Vikings | 117 | 2 | 6 | 30 | 12 | -3 | -1 | 12 | 8 | 19 | -4 | 11 | 11 | bye | 14 |
| Denver | Goats | 106 | 8 | 17 | 26 | 2 | 0 | -1 | 2 | 11 | 5 | 2 | bye | 16 | 9 | 9 |
| Tampa Bay | Contributors | 90 | -2 | 14 | -2 | 10 | 9 | 8 | 16 | -1 | bye | 8 | 15 | 6 | 9 | 0 |
| Dallas | Lemurs | 90 | 8 | 7 | bye | 7 | -1 | 23 | 6 | 4 | 12 | 24 | ||||
| Arizona | Prime Time | 81 | -1 | 14 | 7 | 13 | 18 | 1 | 10 | -1 | 12 | bye | 7 | 1 | ||
| Carolina | Twism | 74 | 16 | 5 | 15 | 9 | 19 | 2 | 3 | bye | 5 | |||||
| Indianapolis | Destroyers | 73 | 2 | 7 | 1 | 14 | 10 | 13 | 26 | bye | ||||||
| LA Rams | Trash Talkers | 69 | 9 | 3 | 1 | -2 | 5 | 14 | 4 | 6 | 12 | 1 | bye | 0 | 16 | dnp |
| New Orleans | 65 | 2 | 17 | -5 | 6 | bye | 15 | 11 | 0 | 7 | 12 | |||||
| Miami | Lunatics | 54 | 5 | 2 | 2 | 3 | 4 | 25 | 13 | bye | ||||||
| Pittsburgh | 48 | 12 | 0 | 5 | 9 | bye | 11 | 4 | 9 | -2 | ||||||
| Tennessee | 43 | 0 | 11 | 8 | 24 | |||||||||||
| San Francisco | 32 | 3 | 6 | 7 | 16 | |||||||||||
| Baltimore | 30 | 0 | 2 | 16 | -3 | bye | 0 | 6 | 9 | |||||||
| Green Bay | Trash Talkers | 27 | 9 | 8 | 10 | |||||||||||
| Philadelphia | Demons | 19 | 9 | 10 | bye | |||||||||||
| Kansas City | 15 | 15 | ||||||||||||||
| Washington | 12 | 3 | 2 | -4 | 7 | 2 | 2 | |||||||||
| Chicago | 10 | 10 | ||||||||||||||
| Houston | 8 | 8 | ||||||||||||||
| LA Chargers | 6 | 6 | ||||||||||||||
| Seattle | 5 | 5 | ||||||||||||||
| Minnesota | 3 | 3 | ||||||||||||||
| Cincinnati | 3 | 2 | 1 | 0 |